Knights of the Pain Table

A Camelot for Sufferers of Chronic Pain

Low Dose Naltrexone(LDN) Improves Crohn's Disease

Low-Dose Naltrexone Therapy Improves Crohn’s Disease

In the January 11, 2007, edition of the American Journal of Gastroenterology, the article “Low-Dose Naltrexone Therapy Improves Active Crohn’s Disease”, is the first study of LDN published in a US medical journal.  In the study they found that two-thirds of the patients went into remission and fully 89% of the group responded to treatment to some degree.  This trial demonstrated the efficacy of LDN in a small group of patients with Crohn’s Disease.

Naltrexone a pure opiod antagonist, is a synthetic congener of oxymorphone with no opioid agonist properties. It completely blocks, reversibly, the subjective effects of morphine, heroin and other opiods such as codeine.  Naltrexone is indicated in the treatment of alcohol dependence by reducing the urge to drink.

When naltrexone is used in doses approximately one-tenth those used for drug/alcohol rehabilitation purposes it is considered  “Low Dose Naltrexone” (LDN).   Naltrexone, an opioid blocker, blocks the function of these natural hormones when given in large doses (100 mg). However, when naltrexone is given in a very small dose before bedtime (3mg), the body responds to this brief opioid blockade by substantially increasing endorphin and enkephalin production, thereby boosting the immune system.

LDN is now being used as an “off-label” treatment for certain immunologically – related disorders.  The LDN Research Trust are raising funds to get clinical trials underway starting with Multiple Sclerosis.  Dr. Bihari would also like to do trials with some other  diseases since there has been some indications that patients would benefit using LDN. Some Suggested Diseases are : Fibromyalgia, Chronic Fatigue Syndrome, HIV/AIDS, Rheumatoid Arthritis, Systemic Lupus, Ulcerative Colitis and Cancers.

A multi-institutional clinical trial of LDN for MS has begun in Italy.  A clinical trial of LDN in the treatment of fibromyalgia at Stanford Medical Center was implemented in mid-2007.

Getting naltrexone in the proper dosage form is problematic. One needs a compounding pharmacy to produce low dose naltrexone.

Visit to learn more about Low Dose Naltrexone.

Sources:  Click here and here.

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6 Responses to “Low Dose Naltrexone(LDN) Improves Crohn's Disease”

  1. Idetrorce says:

    very interesting, but I don’t agree with you

  2. Lady Sharon says:

    Dear ldetrorce,

    I thanketh you for taking the time to visit our humble kingdom and putting some thought in your comments. We doth hope that when it comes to anything, you use your intelligence, your common sense, your experience, your research and your resources and then make the best decision that can be made at that time. We can merely present some information that may or may not help those who are suffering. No one on this earth has all the answers.

    It is good to not agree and be a critical thinker. Our goal is only to help those who are in chronic pain. We thanketh you for visiting Camelot and glad you found the information of interest.
    Please visit us again.

    Your Scribe of Camelot,
    Lady Sharon

  3. john says:


    First off I like your site, lots of information
    I don’t know if you are aware of the Database we are running at We are trying to get as many people as possible to enter their experience there so as to help others make up their minds about LDN. Maybe you would put a link here somewhere

  4. Lady Sharon says:

    Dear John,

    Wilcume to our Kingdom. Thank you for taking the time to advise us of this fantastic resource. I think this is a brilliant idea to measure patient’s response to treatment with LDN.

    We encourage all those who suffer to explore your site to see if LDN might possibly help them. It would be wonderful if they found relief.

    I apologize for the delay in my response, but I have been away from my writing. Sometimes when living in the Middle Ages, there are Darke Knyghts that attract all of your attention.

    The link for your site is:

    I pray thee peace John and we all thanketh you for helping to reduce the suffering of others. Stay well and visit us anytime.

    Lady Sharon
    Scribe of Camelot

  5. metin2 says:

    thanks good post

  6. Lady Sharon says:


    I thank thee for thy thoughts. Please come by again.

    Lady Sharon