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Blood Clotting Protein (Fibrin) Linked To Rheumatoid Arthritis – Study at Cincinnati Children’s

Rheumatoid Arthritis

Researchers at Cincinnati Children’s have issued the first study showing a link between a blood clotting protein (fibrin) and rheumatoid arthritis.   This study, supported by a grant from the National Institutes of Health and the Arthritis Foundation,  could lead to new therapies for this disabling disease.

Jay Degen, Ph.D.,  a researcher in Developmental Biology at Cincinnati Children’s and the study’s lead author, said inflammatory joint disease appears to be driven by the engagement of inflammatory cells with fibrin matrices through a specific integrin receptor, aMB2.     “Our study establishes that fibrin is a powerful, although context-dependent, determinant of inflammatory joint disease,”  said Jay Degen.

“These findings also suggest that pharmacologically interrupting the interaction of fibrin and aMB2 might be efficacious in the treatment of arthritic disease as well as many other inflammatory diseases, such as multiple sclerosis.” said Degen.

Rheumatoid arthritis  (RA) is a chronic disease in which various joints in the body are inflamed, leading to swelling, pain, stiffness, loss of cartilage and bone and ultimately the possible loss of function.    This debilitating disease affects 2.1 million people living in the U.S.     Fibrin deposits are a prominent feature of arthritic joints and the protein appears to be a link between systems that control inflammation and bleeding within joints.

Dr. Degen and the research team are continuing their research to determine more definitively how the interruption of fibrin and aMb2 might translate into potential therapeutic treatment for patients.      This research is published in the November issue of The Journal of Clinical Investigation.

The Journal of Clinical Investigation

Information of Rheumatoid Arthritis from Health Central

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4 Responses to “Blood Clotting Protein (Fibrin) Linked To Rheumatoid Arthritis – Study at Cincinnati Children’s”

  1. arthritis says:

    Arthritis is a group of conditions where there is damage caused to the joints of the body.Arthritis is one of the leading cause of disability in people over the age of 55.There are many different forms of arthritis,each of which has a different cause.Osteoarthritis,rheumatoid arthritis,psoriatic arthritis,Septic arthritis and Gouty arthritis are some of the different forms of arthritis.

  2. Lady Sharon says:

    We thanketh you for your insight on this condition which affects so many.

    Thank you for visiting our Kingdom. Your Kingdom has much information.

    Lady Sharon

  3. coachbob says:

    One of my best friends suffers from rhuematoid arthritis and now his 12 year old daughter has it. Fortunately his arthritis is in the remission stage but his daughter is traveling back to Children’s next week for another appointment. I’ll be happy to send them this link to share with their doctor. Arthritis Treatments

  4. Lady Sharon says:

    Dear Coachbob,

    I do preye that your friend and his daughter are able to find some relief for this crippling condition. I thanketh you for dropping by Camelot and I hope the article did help.

    Dear Alexis,

    A correct diagnosis is most important as many illneses can mimic each other. Arthritis can respond to many types of treatments so it is advisable to travel many roads to find the best solution.

    Good tidings wherever you go.

    Lady Sharon,
    Scribe of The Knights of the Pain Table